Study is double blind but unclear whether outcome assessor or the clinician responsible for patients care is blinded No follow up beyond study completion reported. Relevant outcomes include seizure frequency recorded continuously in a diary and adverse events assessed periodically during interim follow‐up appointments. Non‐medication control group for cognitive testing standards was matched to epilepsy group for sex, age, educational levelĥ6‐day treatment arms, no washout period.ĭouble blind including participant, but unclear whether outcome assessor or the clinician responsible for patients care is blinded. Patients treated with CBZ for at least 1 year Mean age of onset of epilepsy 11.6 years (range birth‐25) Partial in 8, generalised in 2, multifocal in 1 ‐ Computerised Visual Searching Task: Visual‐spatial information processingīlinding: tablets administered in same tablet form and dose frequencyġ1 patients with a diagnosis of epilepsy. ‐ Corsi’s Block Tapping Test: Memory span Tests to assess performance related to fluctuations in serum CBZ level: ‐ Perceptual Speed: Visual scanning ability

Outcome measures to assess cognitive side effects: RCT, cross‐over single blind, participants blinded.Įach arm of at least 1 month duration IR CBZ versus CR CBZ. Summary tables of included studies Aldenkamp 1987 ((singl$ or doubl$ or trebl$ or tripl$) adj (blind$ or mask$)).ab,ti.Ģ3. The filter to identify randomised controlled trials was taken from the Cochrane highly sensitive search strategy for MEDLINE as set out in Appendix 5b of the Cochrane Handbook for Systematic Reviews of Interventions (version 4.2.4, updated March 2005) ( Higgins 2005).ġ0. or (randomized or placebo or randomly).ab.ġ3. (randomized controlled trial or controlled clinical trial).pt.

This strategy is based on the Cochrane Highly Sensitive Search Strategy for identifying randomized trials ( Lefebvre 2011).ġ. #5 MeSH descriptor Seizures explode all trees #4 MeSH descriptor Epilepsy explode all trees #2 MeSH descriptor Carbamazepine explode all trees The following was the original search strategy. #1 (epilep* or seizure* or convuls*):ti,ab,kw (Word variations have been searched) The following search strategy was used for the latest update.

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